Dapsone-induced methemoglobinemia: A case report
Ahmet Peker1, Muhammet Ali Kaypak1, Hakan Yarkıcı1, Bengü Erkul1, Cengiz Ceylan2, Harun Akar1
1Tepecik Eğitim ve Araştırma Hastanesi, İç Hastalıkları Kliniği, İzmir, Türkiye
2Tepecik Eğitim ve Araştırma Hastanesi, Hematoloji Kliniği, İzmir, Türkiye
Keywords: Dapsone; internal medicine; methemoglobinemia.
Dapsone is an aniline derivative belonging to the group of synthetic sulfones. Concerning the mechanism of action, dapsone combines both antibacterial and anti-inflammatory effects. Dapsone rarely induces oxidation of hemoglobin that reduces the enzyme activity of cytochrome b5 reductase located in erythrocytes resulting in significant methemoglobinemia. Herein we report a case of methemoglobinemia in a 36-year-old male patient using dapsone for eight years with discoid lupus diagnosis.