Kaan Sevgi1, Crystal Guillen1, Sinan Aran2

1Kansas City University of Medicine & Biosciences, School of Medicine, Kansas City, United States
2Department of Family Medicine, Demiroglu Science University, İstanbul, Türkiye

Keywords: Graves’ disease, hyperthyroidism, multidisciplinary care, plasmapheresis, thyroid storm.

Abstract

Thyroid storm is a rare and life-threatening endocrinological emergency characterized by severe manifestations of thyrotoxicosis and multi-organ involvement. Prompt recognition and early intervention are paramount to reduce the high morbidity and mortality rates associated with this condition. A 45-year-old woman with a history of Graves’ disease presented with high-grade fever, marked tachycardia, confusion, and persistent vomiting. This case report explores a unique presentation of thyroid storm in a hyperthyroid patient refractory to conventional treatment. The report integrates insights from key reviews and guidelines to present a cohesive approach to optimal care.

Cite this article as: Sevgi K, Guillen C, Aran S. Thyroid storm in a refractory hyperthyroid patient: A case report. D J Med Sci 2025;11(2):97-100. doi: 10.5606/fng. btd.2025.172.

Author Contributions

The case report's conception and design, data collection, literature review, and manuscript composition were all influenced: K.S.; Provided support in the procurement of data, the interpretation of findings, and the critical revision of the manuscript to address significant intellectual content: C.G.; Provided senior supervision, critical revisions, clinical expertise, and approval of the final manuscript version: S.A. The final manuscript was reviewed and endorsed by all authors, who acknowledge their responsibility for its content.

Conflict of Interest

The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

Financial Disclosure

The authors received no financial support for the research and/or authorship of this article.

Data Sharing Statement:
The data that support the findings of this study are available from the corresponding author upon reasonable request.