Beyond hypertrophic cardiomyopathy: Cardiac amyloidosis as the first manifestation of myeloma

Abstract

Cardiac amyloidosis is a frequently overlooked cause of heart failure with preserved ejection fraction, often mimicking hypertrophic cardiomyopathy (HCM). Its clinical presentation may include nonspecific findings such as pleural effusions and dyspnea, contributing to diagnostic delays. We report a 51-year-old woman previously diagnosed with HCM, who presented with progressive dyspnea and recurrent pleural effusions with a near-preserved left ventricular ejection fraction (~50%). This case emphasizes the importance of considering infiltrative cardiomyopathies in the differential diagnosis of unexplained hypertrophy and highlights the role of multimodal imaging in unveiling systemic diseases with cardiac involvement.

Cite this article as: Çetinarslan Ö, Uçar FM. Beyond hypertrophic cardiomyopathy: Cardiac amyloidosis as the first manifestation of myeloma. D J Med Sci 2026;12(1):44-47. doi: 10.5606/fng.btd.2026.178.

Ö.Ç.: Conceptualization, data curation, writing-original draft; F.M.U.: Supervision, review & editing.

The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

Data Sharing Statement
The data that support the findings of this study are available from the corresponding author upon reasonable request.

The authors received no financial support for the research and/or authorship of this article.

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