Beyond hypertrophic cardiomyopathy: Cardiac amyloidosis as the first manifestation of myeloma
Özge Çetinarslan
, Fatih Mehmet Uçar
Department of Cardiology, Demiroğlu Science University, İstanbul Florence Nightingale Hospital, İstanbul, Türkiye
Keywords: Cardiac amyloidosis, global longitudinal strain, hypertrophic cardiomyopathy, multiple myeloma, pleural effusion.
Abstract
Cardiac amyloidosis is a frequently overlooked cause of heart failure with preserved ejection fraction, often mimicking hypertrophic cardiomyopathy (HCM). Its clinical presentation may include nonspecific findings such as pleural effusions and dyspnea, contributing to diagnostic delays. We report a 51-year-old woman previously diagnosed with HCM, who presented with progressive dyspnea and recurrent pleural effusions with a near-preserved left ventricular ejection fraction (~50%). This case emphasizes the importance of considering infiltrative cardiomyopathies in the differential diagnosis of unexplained hypertrophy and highlights the role of multimodal imaging in unveiling systemic diseases with cardiac involvement.
Cite this article as: Çetinarslan Ö, Uçar FM. Beyond hypertrophic cardiomyopathy: Cardiac amyloidosis as the first manifestation of myeloma. D J Med Sci 2026;12(1):44-47. doi: 10.5606/fng.btd.2026.178.